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Enzymatic Reaction Mechanisms, by Perry A. Frey, Adrian D. Hegeman
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Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.
- Sales Rank: #1138584 in Books
- Published on: 2007-01-27
- Original language: English
- Number of items: 1
- Dimensions: 8.50" h x 1.30" w x 11.10" l, 4.35 pounds
- Binding: Hardcover
- 848 pages
About the Author
Perry Frey is Robert H. Ables Professor of Biochemistry at the University of Wisconsin at Madison. Adrian Hegeman is an Assistant Scientist in the Department of Biochemistry at the University of Wisconsin at Madison.
Most helpful customer reviews
14 of 14 people found the following review helpful.
Disappointing
By John Duncan
I came to this book with high expectations based on the deserved reputation of the senior author, and I hoped it would serve as a worthy replacement for Christopher Walsh's excellent book of the same name, published by W. H. Freeman in 1979 and now almost 30 years old. However, I have found it hard to raise much enthusiasm for it. It includes detailed information about the organic reaction mechanisms of many enzyme-catalysed reactions, and it will be valuable as a reference work for years to come, but the text rarely comes alive, so it is unlikely to be perceived by students assigned it as a text on reaction mechanisms as other than a hard grind.
The obvious point of comparison is with Walsh's book, but despite the years that have passed the new book does not come well out of the comparison. If we take the coenzyme pyridoxal phosphate as an example, Walsh points out early in his chapter why we should want to know about it: "the role of pyridoxal-P is to stabilize carbanion intermediates that develop during enzymatic catalysis." Similarly, before entering into detail about the mechanism of reactions that use thiamine pyrophosphate as coenzyme he describes the fundamental problem of decarboxylation in mild conditions, the need for a coenzyme that can stabilize an alpha-keto-acid by supplying an electron sink. This sort of information is not exactly missing from Frey and Hageman's book, but you have to hunt for it, something the student only half-interested in the subject is not very likely to do.
Although the new book is, of course, more up-to-date, this advantage is not as great as one might have anticipated, and a surprising proportion of the references are quite old. This is not necessarily a bad thing, of course, but it does mean that the subject is not one that has been advancing at a frenetic pace -- it would not be easy to imagine a new book on molecular biology, for example, for which about a third of the references were to work published before 1990. Of the chapter on the kinetics of enzyme-catalysed reactions (Chapter 2) perhaps the least said the better. The first half says almost nothing that was not said better by W. W. Cleland in 1963. Then follows a useful discussion of isotope effects (which is much better), and the chapter concludes with an astonishingly outdated account of enzyme regulation, again saying little that could not have been said in the 1960s. It could be argued that a book of this kind hardly needs to cover most of these topics at all, and not much would have been lost if Chapter 2 had simply been omitted, but whatever one decides to include needs to be covered properly.
On the more positive side, advantage has been taken of improvements in production techniques: the book is printed in large pages, on paper of good quality, with many illustrations, including a high proportion in two colours (or three if we count grey), and many stereo pairs. The use of colour is judicious rather than gaudy: there are none of the illustrations in full colour that make a book look flashy and modern but add little or nothing to the message being conveyed. Instead, red is used to highlight points of note, and grey is used for elements that need to be there but are not central to the message. To my mind that is exactly the right way to use colour in a serious book of this kind. Whether or not the stereo pairs are useful will depend on the reader: readers who have no difficulty in working their eye muscles to superimpose two images without losing focus will gain extra information from these pictures; others need to read the text more deeply.
In a book of this kind, with more than 800 pages, a good index is absolutely essential, but unfortunately the index is very poor. The minor criticism is that there is no author index (and authors are not included in the main index). The major criticism is that the subject index was obviously compiled by an employee of the publisher who had little idea of what the book was about. Under "pyridoxal-5'-phosphate (PLP)", for example, there is a cross-reference "see also PLP", and another cross-reference in the opposite direction, but the two lists are not the same, and each contains information that is not in the other. To take a different example, suppose you are interested in the stereochemistry of substitution at phosphorus atoms: how to find it? The index contains no entry under "stereochemistry" and nothing under "substitution" either. Skimming through two columns' worth of entries starting "phosph" you may notice entries under "phosphofructokinase", "phosphoglyerate kinase" and "phosphoglyerate mutase", but these are rather specific and you might be tempted to suppose that no general discussion is given. It is there, however, but to find it you need to look up "phosphoryl group transfer, chemistry of" and then go one page beyond the end of the range given
1 of 1 people found the following review helpful.
Frey Text
By 20Xavier01
The Frey text attempts to 'modernize' the classic text by Walsh. In the time since Walsh's contribution, several texts have made deep impact. For example, the Silverman and Fersht books. In context, I believe Frey has put together a thorough review of mechanism in enzyme catalysis. The first chapter reads well and was my favorite. From a student's perspective (compared to Dr. Frey, we are all students) the explanations of the detailed biophysical phenomena associated with turnover are clear and insightful. Another section I felt was extremely well done covered the 'electron sink' behavior in PLP discussing the intellectual arguments present (to this day) in the field. He balances the pivotal contributions from Kirsch with tact.
A text like this does not have to cover all aspects of enzyme mechanism to be of value, but there are many areas of 'encyclopedic' delivery. My review is split: What I liked, I enjoyed tremendously - thorough, rich in information, blended well with figures etc. The limitations of the text are essentially that - as a text. I don't feel cover-to-cover this could be right text for advanced undergraduate or graduate level work. My hope is that a second edition will provide the improvement similar to the early-to-current Fersht books. Until then, the Silverman text will likely be chosen for most classroom texts.
0 of 0 people found the following review helpful.
Five Stars
By Vincent Perez
It's was perfect, kidz.
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